Mode of Action of electroCore’s non-invasive vagus nerve stimulation – nVNS –therapy
The breakthrough that electroCore achieved in 2010 was to develop a non-invasive Vagus Nerve Stimulation therapy which delivers proprietary electrical signals to the vagus nerve in the neck. This pentawave™ signal activates specific fibers in the vagus nerve bundle. This activation causes the release of inhibitory neurotransmitters within the central nervous system and reduces the overexpression of the excitatory neurotransmitter glutamate, which has been implicated in a number of different disorders.
The gammaCore device which delivers the stimulation to the vagus nerve is placed over the neck above the vagus nerve