Bioelectronic medicine is a field of therapy that uses electrical impulses to alter signals in the nervous system to relieve a variety of conditions. Although the field of bioelectronic medicine and its applications have gathered considerable momentum recently people have been treated, albeit crudely, using electrical impulses for many years. In fact electricity, mainly from electric fish, was used for thousands of years to treat pain and other conditions. After it became possible to store and to control electricity in the mid eighteenth century its popularity increased enormously, both as quackery and for serious applications such as numbing the pain during dental operations. In 1933 Dr. Hyman, heart specialist, sought an alternative to injecting drugs directly into the heart and developed a device called the Hyman Otor which eventually paved the way for modern day defibrillators. The first implantable pacemaker was inserted in 1958. Other examples; deep brain stimulation for Parkinson’s disease and tremor, Cochlear implants for hearing and implanted devices for vagus nerve stimulation (VNS), for partial onset epilepsy and for resistant depression. To date all of these procedures have involved surgery and the implantation of the device. The breakthrough that electroCore has achieved is to develop a range of non invasive, therapies which deliver proprietary electrical signals to the vagus nerve which activates specific fibers in the vagus nerve bundle. This activation causes the release of inhibitory neurotransmitters within the central nervous system, and reduces the over expression of the excitatory neurotransmitter glutamate, which has been implicated in a number of different disorders. Many believe that bioelectronic medicine will be the next big wave in medicine and, if successful, could offer a higher degree of control in modulating biological functions and diseases while avoiding unwanted side effects.